Grant: Project Grant
Université de Montréal
$799,425.00
Intercellular force transmission and coordination during the migration of squamous carcinoma cells.
EF 2020-21
Résumé
Cells that migrate from tumors to form metastasis are usually migrating in groups, a process called collective cell migration. By understanding how cancer migrate in groups, we might be able to develop drugs to inhibit the formation of metastasis. Here we will use cell biology coupled to biophysical approaches to understand how skin cancer cells migrate in groups. In particular, we will investigate the mechanisms by which cells transmit forces among them to be more efficient while migrating in groups.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
433840
Name
Emery Gregory
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Cell Biology - Molecular/Fundamental
Projecttitle
Intercellular force transmission and coordination during the migration of squamous carcinoma cells.
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$799,425
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Actin; Adhesion; Biomechanics; Cell-Cell Communication; Cellular Forces; Collective Cell Migration; Live Imaging; Tfm (Traction Force Microscopy)
Abstract
Cells that migrate from tumors to form metastasis are usually migrating in groups, a process called collective cell migration. By understanding how cancer migrate in groups, we might be able to develop drugs to inhibit the formation of metastasis. Here we will use cell biology coupled to biophysical approaches to understand how skin cancer cells migrate in groups. In particular, we will investigate the mechanisms by which cells transmit forces among them to be more efficient while migrating in groups.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Emery, Gregory
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $799,425~ $0~
