Grant: Operating Grant - Priority Announcement: Blood Utilization and Conservation
McGill University
$0.00
Polyhemoglobin-Catalase-SuperoxideDismutase-CarbonicAnhydrase: a novel soluble biotherapeutic with no cardiac toxicity for hemorrhagic shock and other uses.
EF 2013-14
Résumé
EXTENSIVE BLOOD LOSS from car, plane, bus and train accidents; earthquake; war, terrorism need quick blood replacement. But patients have to be first transported to the hospital for blood group test. Delays in bad weather, traffic jams, earthquake, war or remote Canadian North can result in death. In a recent U.S. study a simple oxygen carrier given on the spot to traffic accident patients could delay the need for blood for 12 hours. HOWEVER, there was toxic side effect on the heart. Since oxygen carrier only transports oxygen it can release damaging oxygen radicals. Red blood cells (RBC) can transport both oxygen and carbon dioxide and remove oxygen radicals. Thus, we designed a new soluble complex with all 3 RBC actions enhanced. This has no blood group antigen and can be used right away on the spot. Although O group donor blood can also be used universally, the advantages of this complex are: (1) RBC need to be kept in a refrigerator, the complex is stable at room temperature and be easily stored on the shelf or transported. (2) It is stable for 1 year in room temperature. RBC stored in the frig is only stable for 42 days. (3) Being a solution, it can better supply oxygen to tissues. (4) It has an enhanced ability to remove oxygen radical to prevent tissue injury. (5) It has enhanced CO2 carrying ability to remove harmful tissue CO2 (6) It can be sterilized to remove infective agents. It can also be useful when the arterial supply is obstructed as in heart attack and stroke. Compared to 7 micron RBC particles, the soluble complex can more easily pass through obstructed vessels. Furthermore, the enhanced ability to remove oxygen radicals and tissue CO2 prevents tissue injury. The components for this new complex can be extracted from outdated donor blood, placental blood and other sources. This will conserve donor blood for other uses and at the same time utilize outdated donor RBC and placenta RBC that would otherwise be discarded. www.artcell.mcgill.ca
Programme
Operating Grant - Priority Announcement: Blood Utilization and Conservation
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
297777
Name
Chang Thomas Ming Swi
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Canadian Blood Services (Ottawa)
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Pharmaceutical Sciences
Projecttitle
Polyhemoglobin-Catalase-SuperoxideDismutase-CarbonicAnhydrase: a novel soluble biotherapeutic with no cardiac toxicity for hemorrhagic shock and other uses.
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$0
Cihrequipment2
$0
Programname2
Operating Grant - Priority Announcement: Blood Utilization and Conservation
Keyworddelim
Anitoxidant Enzymes Catalase Superoxide Dismutase; Carbonic Anhydrase; Hemorrhagic Shock; No Toxic Effect On The Heart; Novel Soluble Biotherapeutic With No Cardiac Toxicity; Tissue Carbon Dioxide; Use Of Red Blood Cell Components
Abstract
EXTENSIVE BLOOD LOSS from car, plane, bus and train accidents; earthquake; war, terrorism need quick blood replacement. But patients have to be first transported to the hospital for blood group test. Delays in bad weather, traffic jams, earthquake, war or remote Canadian North can result in death. In a recent U.S. study a simple oxygen carrier given on the spot to traffic accident patients could delay the need for blood for 12 hours. HOWEVER, there was toxic side effect on the heart. Since oxygen carrier only transports oxygen it can release damaging oxygen radicals. Red blood cells (RBC) can transport both oxygen and carbon dioxide and remove oxygen radicals. Thus, we designed a new soluble complex with all 3 RBC actions enhanced. This has no blood group antigen and can be used right away on the spot. Although O group donor blood can also be used universally, the advantages of this complex are: (1) RBC need to be kept in a refrigerator, the complex is stable at room temperature and be easily stored on the shelf or transported. (2) It is stable for 1 year in room temperature. RBC stored in the frig is only stable for 42 days. (3) Being a solution, it can better supply oxygen to tissues. (4) It has an enhanced ability to remove oxygen radical to prevent tissue injury. (5) It has enhanced CO2 carrying ability to remove harmful tissue CO2 (6) It can be sterilized to remove infective agents. It can also be useful when the arterial supply is obstructed as in heart attack and stroke. Compared to 7 micron RBC particles, the soluble complex can more easily pass through obstructed vessels. Furthermore, the enhanced ability to remove oxygen radicals and tissue CO2 prevents tissue injury. The components for this new complex can be extracted from outdated donor blood, placental blood and other sources. This will conserve donor blood for other uses and at the same time utilize outdated donor RBC and placenta RBC that would otherwise be discarded. www.artcell.mcgill.ca
Competitiondate
201309
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Chang, Thomas Ming Swi
Approvedterm
3 ans 0 mois
