Grant: Project Grant

High-potency cannabis can have detrimental effects on mental health and addiction outcomes. The legal market is geared toward the commercialization of high-THC products while the cannabis industry resists their regulation. Studies have reported mixed findings over whether consumers effectively self-titrate THC doses of higher potency products. The major aim of this laboratory study is to evaluate the ability of cannabis consumers to effectively titrate their THC dose to achieve similar effects when consuming cannabis concentrates of different potencies. We will use a randomized, double-blind, cross-over design where regular cannabis users (stratified by sex) will vape liquid cannabis of a wide range of THC concentrations. We will test products that are commercially available to Canadian consumers. The results from this study will inform public health and policy decisions related to the regulation and use of high-potency concentrates and promote safer cannabis use. We have an ambitious KTE strategy and will share the results with key stakeholders across Canada.