Grant: China-Canada Joint Health Research Initiative
Research Institute of the McGill University Health Centre
$146,550.00
Genetic and drug screen for modulators of aggressive behavior in genetic model systems
EF 2009-10
Résumé
Aggression is an important behavior evolutionarily conserved in animals, and is essential to the survival and evolution of animals. In humans, excess aggression is observed in patients with certain neurological diseases. In this application, the two groups (i.e. Dr. Yong Rao at McGill University Health Centre and Dr. Yi Rao at Beijing University) will perform a genome-wide genetic screen to identify new genes that are involved in the control of aggressive behavior. The two groups will also perform a large-scale drug screen to isolate new compounds that modulate aggressive behavior. Such research will not only provide novel and important insights into the molecular mechanism of aggression, and also provide invaluable information for the development of new therapeutic approaches to treat neurological and psychiatric diseases associated with excess aggression.
Programme
China-Canada Joint Health Research Initiative
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
203980
Name
Rao Yong
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
National Natural Science Foundation of China (Haidian, Beijing)
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
China-Canada Joint Health Research Initiative - Grants Program
Projecttitle
Genetic and drug screen for modulators of aggressive behavior in genetic model systems
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$146,550
Cihrequipment2
$0
Programname2
China-Canada Joint Health Research Initiative
Keyworddelim
Aggression; Behavioral Research; Drosophila; Drug Screen; Genetic Model; Genetic Screen; Nervous System
Abstract
Aggression is an important behavior evolutionarily conserved in animals, and is essential to the survival and evolution of animals. In humans, excess aggression is observed in patients with certain neurological diseases. In this application, the two groups (i.e. Dr. Yong Rao at McGill University Health Centre and Dr. Yi Rao at Beijing University) will perform a genome-wide genetic screen to identify new genes that are involved in the control of aggressive behavior. The two groups will also perform a large-scale drug screen to isolate new compounds that modulate aggressive behavior. Such research will not only provide novel and important insights into the molecular mechanism of aggression, and also provide invaluable information for the development of new therapeutic approaches to treat neurological and psychiatric diseases associated with excess aggression.
Competitiondate
201003
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Rao, Yong; Rao, Yi
Approvedterm
3 ans 0 mois
Cihrcontribution2
Inst of Neurosc Mental Hlth &A~ $146,550~ $0~
