Grant: Project Grant

Osteoporosis and other bone diseases occur when the natural balance between bone breakdown and formation is disrupted, leading to weaker bones and a higher risk of fractures. Bone breakdown is carried out by specialized cells called osteoclasts, which interact with collagen-a key protein that provides structure and strength to bones. Our previous research has shown that certain parts of the collagen molecule can slow down osteoclast activity, but we do not yet fully understand how collagen regulates these cells or whether this knowledge could lead to new treatments. This project aims to identify specific collagen fragments that influence osteoclast function, determine how they work, and test whether they can help treat osteoporosis in mice. By uncovering the potential of collagen-based therapies, our research could lead to the development of innovative, science-backed collagen supplements that are more affordable and effective in maintaining bone health. Ultimately, our work has the potential to improve osteoporosis treatment, support healthy aging, and enhance overall bone strength in a safe and natural way.