Grant: Randomized Controlled Trials
Research Institute of the McGill University Health Centre
$86,747.00
An international randomized controlled trial comparing neurodevelopmental outcome and apnea after Regional compared to General Anesthesia in infants.
EF 2008-09
Résumé
Many infants require surgery in early life. It has been assumed
that there are no adverse effecs of general anesthesia in this age
group. However there is increasing evidence from animal studies
of detrimental effects on brain development at a cellular level
and on memory and learning. Human studies following infants
exposed to anesthesia at an early age also show poorer
performance in a range of neuropsychological tests and in
school performance. All these studies have defects: translation
of animal data to humans; study groups having congenital
anomalies, being sicker than control groups. It is therefore
essential to prospectively study human infants having one type
of surgery which can be performed with either general or
regional anesthesia to determine if anesthesia itself has an
adverse effect on neurodevelopment in this age group.
Programme
Randomized Controlled Trials
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
178695
Name
Withington Davinia E
Region
Québec
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Human Development, Child and Youth Health
Theme2
Clinical
Prcname2
Randomized Controlled Trials - B (RFB)
Projecttitle
An international randomized controlled trial comparing neurodevelopmental outcome and apnea after Regional compared to General Anesthesia in infants.
Programtype2
Randomized Controlled Trials
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$86,747
Cihrequipment2
$0
Programname2
Randomized Controlled Trials
Keyworddelim
Apnea; General Anesthesia; Inguinal Hernia Repair; Neurodevelopment; Newborn; Spinal Anestheia
Abstract
Many infants require surgery in early life. It has been assumed
that there are no adverse effecs of general anesthesia in this age
group. However there is increasing evidence from animal studies
of detrimental effects on brain development at a cellular level
and on memory and learning. Human studies following infants
exposed to anesthesia at an early age also show poorer
performance in a range of neuropsychological tests and in
school performance. All these studies have defects: translation
of animal data to humans; study groups having congenital
anomalies, being sicker than control groups. It is therefore
essential to prospectively study human infants having one type
of surgery which can be performed with either general or
regional anesthesia to determine if anesthesia itself has an
adverse effect on neurodevelopment in this age group.
Competitiondate
200902
Approvedterm2
6 yrs 0 mth
Pinamesdelim
Withington, Davinia E
Approvedterm
6 ans 0 mois
Cihrcontribution2
~ $86,747~ $0~
