Grant: Travel Awards - Institute Community Support

Aging is accompanied by increased inflammation throughout the blood and peripheral tissues. These inflammatory molecules can communicate with the brain to promote neuroinflammation, which can be defined as inflammation within the brain tissue. Neuroinflammation has detrimental effects on various brain regions, particularly the hippocampus, a structure involved in learning and memory. Specifically, inflammatory molecules damage both existing and new neurons produced within the hippocampus. Neuroinflammation may also reduce the level of neurotrophic factors in the brain, which support the growth, survival, and development of neurons, further contributing to reduced brain health. The result of this age-related inflammation is impaired memory and an increased risk for neurodegenerative disease, such as dementia. Physical activity has been identified as a lifestyle factor capable of preventing cognitive decline. Exercise can reduce inflammation, which may enhance cognitive function. However, the precise mechanisms governing such effects remain unclear. The proposed study will determine the influence of physical activity on hippocampal memory function among older adults, as well as investigate the impact of inflammation and neurotrophic factors on this relationship. This research will elucidate the mechanisms by which physical activity is capable of slowing age-related cognitive decline. Importantly, by investigating these underlying mechanisms, it may be possible to optimize exercise interventions and establish physical activity as a primary prescription for maintaining cognitive function in old age.