Grant: Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream
Centre hospitalier de l'Université de Montréal (CHUM)
$100,000.00
Chemokine Network and HIV Pathogenesis: New Insights into the Functional Heterogeneity of Monocyte-Derived Dendritic Cells and CD4+ T-Cells
EF 2009-10
Résumé
Our hypothesis is that discrete uncharacterized subsets of monocyte-derived dendritic cells (MDDC) and CD4+ T-cells differentially contribute to anti-HIV immunity and viral replication/persistence and that specific chemokines and chemokine receptors govern their in situ localization, interactions, and functionality. Our goal is (1) to investigate the molecular basis for distinct contribution of two major subsets of MDDC, CD16+ and CD16neg, to immunity and HIV pathogenesis; (2) to identify new molecular determinants for HIV permissiveness and resistance in discrete CD4+ T-cell subsets with differential expression of surface markers for homing and lineage commitment (i.e., CCR4, CXCR3, and CCR6); and (3) to determine the consequences of MDDC and CD4+ T-cell functional alterations on the Th17 differentiation pathway in HIV-infected patients. The use of the chemokine network as a strategy toward the and characterization of functionally distinct MDDC and CD4+ T-cell subsets will allow the identification of new molecular determinants for HIV pathogenesis and will suggest new targeted therapeutic strategies toward HIV eradication.
Programme
Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
199383
Name
Ancuta Petronela
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Chemokine Network and HIV Pathogenesis: New Insights into the Functional Heterogeneity of Monocyte-Derived Dendritic Cells and CD4+ T-Cells
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream
Keyworddelim
Chemokines/Chemokine Receptors And Inflammation; Dendritic Cells And Cd4+ T Cells; Facs Sorting And Confocal Microscopy; Hiv And Viral Reservoirs; Immune And Virological Synapse; Real Time Pcr And High Throughput Chemokine Screening
Abstract
Our hypothesis is that discrete uncharacterized subsets of monocyte-derived dendritic cells (MDDC) and CD4+ T-cells differentially contribute to anti-HIV immunity and viral replication/persistence and that specific chemokines and chemokine receptors govern their in situ localization, interactions, and functionality. Our goal is (1) to investigate the molecular basis for distinct contribution of two major subsets of MDDC, CD16+ and CD16neg, to immunity and HIV pathogenesis; (2) to identify new molecular determinants for HIV permissiveness and resistance in discrete CD4+ T-cell subsets with differential expression of surface markers for homing and lineage commitment (i.e., CCR4, CXCR3, and CCR6); and (3) to determine the consequences of MDDC and CD4+ T-cell functional alterations on the Th17 differentiation pathway in HIV-infected patients. The use of the chemokine network as a strategy toward the and characterization of functionally distinct MDDC and CD4+ T-cell subsets will allow the identification of new molecular determinants for HIV pathogenesis and will suggest new targeted therapeutic strategies toward HIV eradication.
Competitiondate
200909
Approvedterm2
1 yr 0 mth
Pinamesdelim
Ancuta, Petronela
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
