Grant: Project Grant
McMaster University
$875,355.00
Novel multivalent chimpanzee adenovirus-based vaccines against pulmonary tuberculosis
EF 2015-16
Résumé
TB remains a leading infectious cause of global morbidity and mortality. TB epidemic is made even worse by HIV/AIDS and multi-drug resistant bacteria. This occurs despite decades-long use of BCG vaccine and antibiotics. Although the overall TB incidence is low in Canada compared to the developing countries, TB remains an important health issue. Our project aims to develop a new generation of vaccines that can be delivered via the respiratory tract for the best protection in previous BCG-vaccinated hosts. The new TB vaccination strategy we propose to develop will ultimately contribute to the effective control of lung TB in the world.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
343353
Name
Xing Zhou
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Novel multivalent chimpanzee adenovirus-based vaccines against pulmonary tuberculosis
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$875,355
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bcg; Lung Infectious Disease; Mucosal Immunity; Mycobacterium Tuberculosis; Recombinant Viral-Vectored Vaccines; Respiratory Mucosal Immunization; T Cell Immunity; Tuberculosis; Vaccines
Abstract
TB remains a leading infectious cause of global morbidity and mortality. TB epidemic is made even worse by HIV/AIDS and multi-drug resistant bacteria. This occurs despite decades-long use of BCG vaccine and antibiotics. Although the overall TB incidence is low in Canada compared to the developing countries, TB remains an important health issue. Our project aims to develop a new generation of vaccines that can be delivered via the respiratory tract for the best protection in previous BCG-vaccinated hosts. The new TB vaccination strategy we propose to develop will ultimately contribute to the effective control of lung TB in the world.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Xing, Zhou
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $875,355~ $0~
