Grant: Operating Grant
McMaster University
$680,630.00
Role of AMP-activated protein kinase in regulating inflammation in obesity: implications for the treatment of insulin resistance
EF 2010-11
Résumé
Nearly 50% of Canadian are overweight or obese. Obesity is strongly associated with inflammation and defects in fat metabolism which contribute to insulin resistance (pre-diabetes). In the current proposal we will examine the role for a metabolic sensing molecule, AMP-activated protein kinase (AMPK), in regulating inflammation and fat metabolism in immune cells. We believe that activation of this molecule in immune cells will reduce inflammation and fat accumulation preventing the development of diabetes.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
223820
Name
Steinberg Gregory R
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Role of AMP-activated protein kinase in regulating inflammation in obesity: implications for the treatment of insulin resistance
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$680,630
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Acetyl-Coa Carboxylase; Amp-Activated Protein Kinase; Fatty Acids; Inflammation; Innate Immunity; Insulin Resistance; Macrophage; Mouse Models; Obesity; Pgc1 And Mitochondria
Abstract
Nearly 50% of Canadian are overweight or obese. Obesity is strongly associated with inflammation and defects in fat metabolism which contribute to insulin resistance (pre-diabetes). In the current proposal we will examine the role for a metabolic sensing molecule, AMP-activated protein kinase (AMPK), in regulating inflammation and fat metabolism in immune cells. We believe that activation of this molecule in immune cells will reduce inflammation and fat accumulation preventing the development of diabetes.
Competitiondate
201103
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Steinberg, Gregory R
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $680,630~ $0~
