Grant: Travel Awards - Institute Community Support

The synthesis of testosterone, produced by testis Leydig cells, is essential for proper male sex differentiation during fetal life. Testosterone is also required to induce puberty and for spermatogenesis. Insufficient testosterone production, caused by gene mutation or exposure to compounds disrupting the endocrine system, leads to male undermasculinization and/or fertility problems. Contrariwise, excess testosterone causes aggressiveness, sub/infertility, heart problems, or prostate hyperplasia. The aim of this study is to elucidate the regulation of testosterone synthesis and elimination in the testis. Because, an adequate testosterone production is essential throughout life for normal male reproductive health and fertility. In conclusion, this hormone must be tightly regulated throughout life.