Grant: Operating Grant
Research Institute of the McGill University Health Centre
$882,060.00
Dissection of the molecular mechanisms controlling the establishment of neuronal circuitry during development
EF 2014-15
Résumé
Understanding the molecular control of neural network formation during embryonic development can provide invaluable clues for restoring appropriate neuronal circuitry for functional recovery in patients with nerve injuries. In this application, I propose to utilize fruitfly as a model system to study neuronal circuit development and function. We will investigate the exact action of three evolutionarily conserved genes Turtle, Borderless and Semaphorin in regulating the assembly of neuronal circuitry. By taking a combination of biochemical, molecular and genetic approaches, we will determine how these genes interact with other genes to facilitate the wiring of neural networks. The proposed research will provide novel and important insights into molecular mechanisms underlying circuit development, and help the development of new therapeutical approaches to treat neurological diseases and nerve injuries in humans.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
320266
Name
Rao Yong
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Dissection of the molecular mechanisms controlling the establishment of neuronal circuitry during development
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$882,060
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Axon Guidance; Cell Biology; Cell Culture; Drosophila Genetics; Immunohistochemistry; Molecular Biology; Tiling And Self-Avoidance
Abstract
Understanding the molecular control of neural network formation during embryonic development can provide invaluable clues for restoring appropriate neuronal circuitry for functional recovery in patients with nerve injuries. In this application, I propose to utilize fruitfly as a model system to study neuronal circuit development and function. We will investigate the exact action of three evolutionarily conserved genes Turtle, Borderless and Semaphorin in regulating the assembly of neuronal circuitry. By taking a combination of biochemical, molecular and genetic approaches, we will determine how these genes interact with other genes to facilitate the wiring of neural networks. The proposed research will provide novel and important insights into molecular mechanisms underlying circuit development, and help the development of new therapeutical approaches to treat neurological diseases and nerve injuries in humans.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rao, Yong
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $882,060~ $0~
