Grant: Operating Grant
University of Alberta
$1,220,672.00
Phosphatidylcholine and Metabolic Disorders
EF 2013-14
Résumé
Obesity, type 2 diabetes, and cardiovascular disease are the most serious health problems in Canada. We have discovered that if you completely eliminate an enzyme (PEMT) in the biosynthesis of a membrane lipid (called PC) in the liver, there is striking protection against these 3 diseases. This grant is designed to understand the various mechanisms by which this protection is afforded. Secondly, we plan to investigate using a special virus (adeno associated virus) to deliver an inhibitor to the livers of mice and other mammals and see to what degree the animals are protected against these diseases.
Programme
Operating Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
290455
Name
Vance Dennis E
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Phosphatidylcholine and Metabolic Disorders
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$1,220,672
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adeno-Associated Virus; Diabetes; Obesity; Phosphatidylcholine; Phospholipid Methylation; Vagotomy
Abstract
Obesity, type 2 diabetes, and cardiovascular disease are the most serious health problems in Canada. We have discovered that if you completely eliminate an enzyme (PEMT) in the biosynthesis of a membrane lipid (called PC) in the liver, there is striking protection against these 3 diseases. This grant is designed to understand the various mechanisms by which this protection is afforded. Secondly, we plan to investigate using a special virus (adeno associated virus) to deliver an inhibitor to the livers of mice and other mammals and see to what degree the animals are protected against these diseases.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Vance, Dennis E
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,220,672~ $0~
