Grant: Operating Grant
McGill University
$784,635.00
Mechanism of miRNA action in translation and mRNA decay.
EF 2008-09
Résumé
A newly discovered class of small RNA molecule, called microRNAs, has recently been shown to be involved in muscle differentiation, stem cell development, and cancer formation. MicroRNAs bind to certain tails of the genetic material (messenger RNA) that serves as a the template for the synthesis of all proteins in the cell. We are studying how microRNAs, once bound to messenger RNAs, shut down protein synthesis and lead to messenger RNA degradation. Understanding the basic mechanisms of how miRNAs function will allow us to design new treatments for a variety of microRNA-related diseases
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
172327
Name
Sonenberg Nahum
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Mechanism of miRNA action in translation and mRNA decay.
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$784,635
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cancer; In Vitro Microrna Asays; In Vitro Transcription; Microrna; Rna Metabolism; Translational Control
Abstract
A newly discovered class of small RNA molecule, called microRNAs, has recently been shown to be involved in muscle differentiation, stem cell development, and cancer formation. MicroRNAs bind to certain tails of the genetic material (messenger RNA) that serves as a the template for the synthesis of all proteins in the cell. We are studying how microRNAs, once bound to messenger RNAs, shut down protein synthesis and lead to messenger RNA degradation. Understanding the basic mechanisms of how miRNAs function will allow us to design new treatments for a variety of microRNA-related diseases
Competitiondate
200809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sonenberg, Nahum
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $784,635~ $0~
