Grant: Research Tools and Instruments - Category 1 (<$150,000)

The requested fluorescence microscope will allow us to expand our current research and make new advances in the development of novel biomimetic tissue engineering scaffolds and fracture prediction and treatment of bone. To be able to conduct this research effectively, we require knowledge concerning the cellular response to the biomaterial surfaces as well as to be able to assess the extent of microcracking in trabeular bone. To obtain this knowledge, we require a reflectance fluorescence microscope equipped with brightfield differential interference contrast imaging. The outcome of these research projects will enable us to design better suitable biomaterial scaffolds to optimize the tissue regeneration process as well as help develop model to more accurately predict bone fracture risk in health and disease. As the training of graduate students are important aspect of our research, this device will also support our graduate programs in both Mechanical and Materials Engineering and Chemical Engineering. The projects outlined within this proposal will provide training for a total of at least 22 graduate students and post-doctoral fellows. Thus, we are requesting funds to purchase this important and necessary equipment.