Grant: Operating Grant
Queen's University (Kingston, Ontario)
$100,000.00
Elucidating the mechanisms and reverting the hematopoietic consequences of target gene deregulation by the oncogenic transcription factor E2A-PBX1
EF 2015-16
Résumé
Acute lymphoblastic leukemia (ALL), the most common childhood cancer, results fundamentally from the excessive accumulation of nascent white blood cells due to a failure of these cells to correctly regulate the function of certain genes. E2A-PBX1 is a mutant protein produced in leukemia cells that disrupts gene regulation. This research is designed to identify the genes that are deregulated by E2A-PBX1, elucidate the mechanism by which E2A-PBX1 deregulates these genes, and explore the feasibility of killing leukemia cells by blocking the adverse effects of E2A-PBX1 on gene regulation.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
332988
Name
Lebrun David P
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics
Projecttitle
Elucidating the mechanisms and reverting the hematopoietic consequences of target gene deregulation by the oncogenic transcription factor E2A-PBX1
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cancer; Chromatin; Gene Transcription; Hematopoiesis; Leukemia; Oncogenes; Protein-Protein Interactions; Structural Biology
Abstract
Acute lymphoblastic leukemia (ALL), the most common childhood cancer, results fundamentally from the excessive accumulation of nascent white blood cells due to a failure of these cells to correctly regulate the function of certain genes. E2A-PBX1 is a mutant protein produced in leukemia cells that disrupts gene regulation. This research is designed to identify the genes that are deregulated by E2A-PBX1, elucidate the mechanism by which E2A-PBX1 deregulates these genes, and explore the feasibility of killing leukemia cells by blocking the adverse effects of E2A-PBX1 on gene regulation.
Competitiondate
201505
Approvedterm2
1 yr 0 mth
Pinamesdelim
Lebrun, David P
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
