Grant: Operating Grant
McMaster University
$670,700.00
Skeletal Muscle Energy Sensing and Insulin Sensitivity in Obesity
EF 2012-13
Résumé
Nearly 50% of Canadian are overweight or obese. The most common side effect of obesity is insulin resistance or pre-diabetes. Muscle is the main user of energy in the body and is important for controlling blood sugar levels. In obesity muscle accumulates fat and does not respond to the hormone insulin, which contributes to the development of pre-diabetes. In the current proposal, we will examine the role for a metabolic sensing molecule, AMP-activated protein kinase (AMPK), in
regulating fat metabolism and insulin sensitivity in skeletal muscle. These results will identify new ways to improve insulin sensitivity which will lead to new therapies for type 2 diabetes.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
265548
Name
Steinberg Gregory R
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Skeletal Muscle Energy Sensing and Insulin Sensitivity in Obesity
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$670,700
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Amp-Activated Protein Kinase; Fatty Acid Oxidation; Insulin Resistance; Metformin; Mouse Models; Obesity; Protein Acetylation; Protein Phosphorylation; Salicylate; Type 2 Diabetes
Abstract
Nearly 50% of Canadian are overweight or obese. The most common side effect of obesity is insulin resistance or pre-diabetes. Muscle is the main user of energy in the body and is important for controlling blood sugar levels. In obesity muscle accumulates fat and does not respond to the hormone insulin, which contributes to the development of pre-diabetes. In the current proposal, we will examine the role for a metabolic sensing molecule, AMP-activated protein kinase (AMPK), in
regulating fat metabolism and insulin sensitivity in skeletal muscle. These results will identify new ways to improve insulin sensitivity which will lead to new therapies for type 2 diabetes.
Competitiondate
201209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Steinberg, Gregory R
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $670,700~ $0~
