Grant: Operating Grant
Research Institute of the McGill University Health Centre
$707,578.00
Investigating the Role of Neutrophil Extracellular Traps In Cancer Metastasis
EF 2013-14
Résumé
Infections after cancer surgery can increase the likelihood that the cancer recurs, and white blood cells appear to be involved in this process. We have previously shown that neutrophils, the most common of the white blood cells recruited to help fight off an infection, can actually aid the cancer cells to attach and develop secondary tumours in the liver. Neutrophils release a web of their own DNA in response to an infection called a Neutrophil Extracellular Trap (NET), and we have also shown that these NETs can capture cancer cells, making them more likely to spread to the liver. The current study involves investigating how these NETs capture and activate cancer cells, and will identify targets to prevent the spread of cancer during surgery.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
291667
Name
Ferri Lorenzo
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics 2
Projecttitle
Investigating the Role of Neutrophil Extracellular Traps In Cancer Metastasis
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$707,578
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Beta 1 Integrin; Cancer Metastasis; Ceacam; Intracellular Signalling; Intravital Microscopy; Liver; Neutrophil Extracellular Traps; Neutrophils
Abstract
Infections after cancer surgery can increase the likelihood that the cancer recurs, and white blood cells appear to be involved in this process. We have previously shown that neutrophils, the most common of the white blood cells recruited to help fight off an infection, can actually aid the cancer cells to attach and develop secondary tumours in the liver. Neutrophils release a web of their own DNA in response to an infection called a Neutrophil Extracellular Trap (NET), and we have also shown that these NETs can capture cancer cells, making them more likely to spread to the liver. The current study involves investigating how these NETs capture and activate cancer cells, and will identify targets to prevent the spread of cancer during surgery.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ferri, Lorenzo
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $707,578~ $0~
