Grant: Project Grant
University of Toronto
$1,036,576.00
Illuminating the functions of tumor associated carbohydrate antigens using next-generation screening technologies
EF 2024-25
Résumé
All cells in every organisms are coated in complex sugar structures called glycans. Cells spend a large amount of energy to make glycans, suggesting that they are very important structures for the survival and function of an organism. Surprisingly, our knowledge of how glycans regulate the biology of a cell is limited. This is especially true in the context of cancer, where the specific glycans that cancer cells make can be very different compared to healthy cells. This project focusses on developing new technologies that will enable us to understand how glycans influence immune cell functions that are relevant to keeping the body free of cancer. We will leverage the information gathered from this technology platform to identify new biological pathways that we can target in the future for cancer immunotherapies.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
522723
Name
Edgar Landon J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
Illuminating the functions of tumor associated carbohydrate antigens using next-generation screening technologies
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$1,036,576
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cancer Immunotherapy; Carbohydrate Chemistry; Crispra; Functional Genetics; Glycobiology; High-Parameter Flow Cytometry; Immunosuppression; Lectins; Lipid Nanoparticles; Unbiased Screening
Abstract
All cells in every organisms are coated in complex sugar structures called glycans. Cells spend a large amount of energy to make glycans, suggesting that they are very important structures for the survival and function of an organism. Surprisingly, our knowledge of how glycans regulate the biology of a cell is limited. This is especially true in the context of cancer, where the specific glycans that cancer cells make can be very different compared to healthy cells. This project focusses on developing new technologies that will enable us to understand how glycans influence immune cell functions that are relevant to keeping the body free of cancer. We will leverage the information gathered from this technology platform to identify new biological pathways that we can target in the future for cancer immunotherapies.
Competitiondate
202503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Edgar, Landon J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,036,576~ $0~
