Grant: Operating Grant

Growth cones are specialized tips at the end of growing nerve cells that are critical for appropriate wiring of the nervous system. Appropriate connectivity in the nervous system is a fundamental process for appropriate neuronal development and is a key component of nervous system regeneration following trauma. In a screen to identify proteins within the growth cone that are critical for their dynamic functions, we have identified a family of adapter proteins, coined 14-3-3 proteins, that play critical roles in regulating the cytoskeleton. The cytoskeleton is the underlying support system within growth cones. In this proposal we will explore the roles of 14-3-3 proteins in nervous system development and regeneration. This research will lead to a better understanding of nervous system development and may identify new therapeutic targets for repair following CNS injury.