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Grant: Project Grant

University of Ottawa

$1,298,970.00

Cellular and network bases of memory storage and retrieval

EF 2016-17

Résumé
We live in a noisy world and often have to identify people, places and things with only brief and partial sensory input. We can do so because a key brain region in our temporal lobe - the hippocampus - is able to take noisy sense input and, based on our excellent memory, correctly guess at the input. In this way, we can identify individuals even if seen from a distance and only briefly. Damage to the temporal lobe and neurological problems such as temporal lobe epilepsy can disrupt this important process. This grant application proposes to study this fundamental aspect of memory and therefore start to address how to maintain optimal recognition in aging and in recovery from neurological disorders involving the temporal lobe.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database

Tel que publié

Id
357300
Name
Maler Leonard
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Cellular and network bases of memory storage and retrieval
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$1,298,970
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Burst Discharge; Electrophysiology; Hippocampus; Neural Coding; Optogenetics; Synapse; Synaptic Plasticity; Synaptic Transmission; Two Photon Imaging; Whole Cell Recording
Abstract
We live in a noisy world and often have to identify people, places and things with only brief and partial sensory input. We can do so because a key brain region in our temporal lobe - the hippocampus - is able to take noisy sense input and, based on our excellent memory, correctly guess at the input. In this way, we can identify individuals even if seen from a distance and only briefly. Damage to the temporal lobe and neurological problems such as temporal lobe epilepsy can disrupt this important process. This grant application proposes to study this fundamental aspect of memory and therefore start to address how to maintain optimal recognition in aging and in recovery from neurological disorders involving the temporal lobe.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Maler, Leonard; Béïque, Jean-Claude; Longtin, André
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,298,970~ $0~