Grant: Project Grant
Université de Montréal
$749,700.00
Roles of CLCF1 and CRLF1 in IL-23-driven autoimmune pathologies.
EF 2017-18
Résumé
We observed a biochemical link between the cytokines CLCF1/CRLF1, IL-12 and IL-23. IL-23 is involved in auto-immune diseases such as psoriasis and inflammatory bowel diseases. Blocking IL-12 and IL-23 with the biological drug ustekinumab is currently used to treat these pathologies. We will investigate the role of the interaction between CLCF1/CRLF1, IL-12 and IL-23 in auto-immune pathologies and its potential as target for alternative therapeutic approaches.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
381410
Name
Gauchat Jean-François M
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Roles of CLCF1 and CRLF1 in IL-23-driven autoimmune pathologies.
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$749,700
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Autoimmunity; Cytokines; Inflammatory Bowel Diseases; Psoriasis
Abstract
We observed a biochemical link between the cytokines CLCF1/CRLF1, IL-12 and IL-23. IL-23 is involved in auto-immune diseases such as psoriasis and inflammatory bowel diseases. Blocking IL-12 and IL-23 with the biological drug ustekinumab is currently used to treat these pathologies. We will investigate the role of the interaction between CLCF1/CRLF1, IL-12 and IL-23 in auto-immune pathologies and its potential as target for alternative therapeutic approaches.
Competitiondate
201803
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Gauchat, Jean-François M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $749,700~ $0~
