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Grant: Project Grant

Ottawa Hospital Research Institute

$348,076.00

A living systematic review, meta-analysis and dose-response of randomized controlled trials testing serotonergic psychedelics: efficacy, acceptability, tolerability, safety and publication bias within and across health conditions

EF 2023-24

Résumé
A growing number of studies are looking at how psychedelics could help with various health conditions, but not all of these studies are readily available to the public. Research suggests that psychedelics could have significant effects on mental health and palliative care. More studies are being planned for other conditions too. We believe it's the optimal time to create a "living systematic review" (LSR) (i.e., a review that is continuously updated) of psychedelics in medical treatments. Here's why: First, there's a real need for new treatments for certain mental and physical conditions. Second, as more studies come out, our understanding could change. Third, many studies are being conducted, and standard reviews are outdated by the time they are published. So far, there hasn't been a LSR of all the trials on psychedelics. This gap makes it hard for policymakers and experts to make decisions based on the latest evidence. Our project will be the first of its kind. We'll analyze all the trials on psychedelics and their effects on different health issues. We'll look at how effective they are, how well they're tolerated, and how safe they are. We'll also explore different doses and measure different sources of bias in the published studies. We'll update our review every three months and make the results available online. This easy to use online resource will let people see the latest findings and break them down by different factors, like the type of psychedelic used and whether therapy was involved. We'll work closely with policy makers, people who have experience with psychedelics, and experts from around the world to make sure our website is useful and accessible. Ultimately, our work will lay the foundation for a global hub of information on psychedelics in medicine, helping to shape guidelines and policies based on the best available evidence.
Programme
Project Grant
Emplacement
Ontario, Canada
Type de bénéficiaire
Other
Type
Grant
Source
CIHR Funding Decisions Database

Tel que publié

Id
501530
Name
Solmi Marco
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Health Services and Policy Research
Theme2
Health systems / services
Prcname2
Health Services Evaluation & Interventions Research 2
Projecttitle
A living systematic review, meta-analysis and dose-response of randomized controlled trials testing serotonergic psychedelics: efficacy, acceptability, tolerability, safety and publication bias within and across health conditions
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$348,076
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Living Systematic Review; Mdma; Meta-Analysis; Psilocybin; Psychedelics
Abstract
A growing number of studies are looking at how psychedelics could help with various health conditions, but not all of these studies are readily available to the public. Research suggests that psychedelics could have significant effects on mental health and palliative care. More studies are being planned for other conditions too. We believe it's the optimal time to create a "living systematic review" (LSR) (i.e., a review that is continuously updated) of psychedelics in medical treatments. Here's why: First, there's a real need for new treatments for certain mental and physical conditions. Second, as more studies come out, our understanding could change. Third, many studies are being conducted, and standard reviews are outdated by the time they are published. So far, there hasn't been a LSR of all the trials on psychedelics. This gap makes it hard for policymakers and experts to make decisions based on the latest evidence. Our project will be the first of its kind. We'll analyze all the trials on psychedelics and their effects on different health issues. We'll look at how effective they are, how well they're tolerated, and how safe they are. We'll also explore different doses and measure different sources of bias in the published studies. We'll update our review every three months and make the results available online. This easy to use online resource will let people see the latest findings and break them down by different factors, like the type of psychedelic used and whether therapy was involved. We'll work closely with policy makers, people who have experience with psychedelics, and experts from around the world to make sure our website is useful and accessible. Ultimately, our work will lay the foundation for a global hub of information on psychedelics in medicine, helping to shape guidelines and policies based on the best available evidence.
Competitiondate
202403
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Solmi, Marco; Veroniki, Areti Angeliki
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $348,076~ $0~