Grant: Project Grant
University of Calgary
$910,350.00
Targeting intestinal mesenchymal cell populations in fibrostenotic Crohn's disease - modulation of proliferative, fibrotic and inflammatory processes by NR4A1.
EF 2016-17
Résumé
Chronic inflammation in the gut causes structural changes that often lead to intestinal blockage, clinically termed obstruction. Nearly 50% of patients with Crohn's disease will require surgery for intestinal obstruction within 10 years of their diagnosis. Of those that undergo surgery, nearly half of them will have the obstruction return.
In the current proposal, we are characterizing a new target that can block the processes that contribute to intestinal obstruction in Crohn's disease. NR4A1 is a protein that can reduce muscle growth and the structural changes thought to contribute to obstruction.
Should our theories prove correct, we may be able to develop new therapies that target the specific processes that contribute to obstruction in Crohn's disease.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
356214
Name
Hirota Simon A
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Targeting intestinal mesenchymal cell populations in fibrostenotic Crohn's disease - modulation of proliferative, fibrotic and inflammatory processes by NR4A1.
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$910,350
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Crohn'S Disease; Fibroblast; Fibrosis; Inflammation; Inflammatory Bowel Diseases; Mesenchyme; Smooth Muscle; Stricture
Abstract
Chronic inflammation in the gut causes structural changes that often lead to intestinal blockage, clinically termed obstruction. Nearly 50% of patients with Crohn's disease will require surgery for intestinal obstruction within 10 years of their diagnosis. Of those that undergo surgery, nearly half of them will have the obstruction return.
In the current proposal, we are characterizing a new target that can block the processes that contribute to intestinal obstruction in Crohn's disease. NR4A1 is a protein that can reduce muscle growth and the structural changes thought to contribute to obstruction.
Should our theories prove correct, we may be able to develop new therapies that target the specific processes that contribute to obstruction in Crohn's disease.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hirota, Simon A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $910,350~ $0~
