Grant: Travel Awards - Institute Community Support
Direct Payment
$1,000.00
A novel diabetes susceptibility locus revealed by an immunogenetic study of a rare CD4-CD8- T cell population
EF 2012-13
Résumé
ICS Travel Awards
We and others have recently demonstrated the potent role of a rare cell type, namely DN T cells, in the prevention of autoimmune diabetes. Specifically we have shown that mice which spontaneously develop diabetes have fewer DN T cells than mice which never develop disease. Moreover, injection of DN T cells in mice is sufficient to prevent diabetes onset. The key advantage of DN T cells over other types of therapies aimed at inhibiting autoimmune responses lies in their specificity. Indeed, DN T cells appear to specifically impede the production of antibodies associated with the autoimmune pathology.
The project described herein aims to identify the genes which determine the proportion of DN T cells. The outcome of this project may yield novel therapeutic avenues in the treatment of type 1 diabetes.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
278695
Name
Collin Roxanne
Region
Québec
Country
Canada
Orgtype
Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Institute of Human Development, Child and Youth Health
Projecttitle
A novel diabetes susceptibility locus revealed by an immunogenetic study of a rare CD4-CD8- T cell population
Programtype2
Undefined
Orgnameinp2
Direct Payment
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
"Ics Travel Awards"; Autoimmunity; Dnt Cells; Immunoregulation; Tolerance; Type 1 Diabetes
Abstract
ICS Travel Awards
We and others have recently demonstrated the potent role of a rare cell type, namely DN T cells, in the prevention of autoimmune diabetes. Specifically we have shown that mice which spontaneously develop diabetes have fewer DN T cells than mice which never develop disease. Moreover, injection of DN T cells in mice is sufficient to prevent diabetes onset. The key advantage of DN T cells over other types of therapies aimed at inhibiting autoimmune responses lies in their specificity. Indeed, DN T cells appear to specifically impede the production of antibodies associated with the autoimmune pathology.
The project described herein aims to identify the genes which determine the proportion of DN T cells. The outcome of this project may yield novel therapeutic avenues in the treatment of type 1 diabetes.
Competitiondate
201301
Approvedterm2
0 yr 3 mths
Pinamesdelim
Collin, Roxanne
Approvedterm
0 an 3 mois
Cihrcontribution2
Inst of Human Dev &Child &Yth~ $1,000~ $0~
