Grant: Project Grant
University of Toronto
$824,670.00
Protein inhibitors of CRISPR-Cas9 mediated genome editing: discovery, characterization and development for novel biotechnological applications
EF 2016-17
Résumé
CRISPR-Cas9 genome editing has revolutionized biomedical research and holds tremendous promise for the treatment of genetic diseases and cancer. This system is derived from a bacterial immune system that protects bacteria against the viruses that infect and kill them. We have identified a number of proteins that are able to stop the activity of CRIPSR-Cas9 in bacteria. We have also shown that these proteins are able to block CRISPR-Cas9 genome editing in human cells. These proteins provide important new modulators of CRISPR activity that will have wide-ranging utility for biotechnological, industrial, and human genome editing applications.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
355734
Name
Maxwell Karen L
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Protein inhibitors of CRISPR-Cas9 mediated genome editing: discovery, characterization and development for novel biotechnological applications
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$824,670
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bacteriophage; Crispr; Phage
Abstract
CRISPR-Cas9 genome editing has revolutionized biomedical research and holds tremendous promise for the treatment of genetic diseases and cancer. This system is derived from a bacterial immune system that protects bacteria against the viruses that infect and kill them. We have identified a number of proteins that are able to stop the activity of CRIPSR-Cas9 in bacteria. We have also shown that these proteins are able to block CRISPR-Cas9 genome editing in human cells. These proteins provide important new modulators of CRISPR activity that will have wide-ranging utility for biotechnological, industrial, and human genome editing applications.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Maxwell, Karen L
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $824,670~ $0~
