Grant: Strategic Projects - Group
University of Waterloo
$197,675.00
DNA-gated stimuli-responsive nanostructures for metal sensing and smart remediation
EF 2017-18
Résumé
Around 40% of the rivers and lakes in America are polluted, and this problem is much more serious in developing countries. In particular, water contamination by heavy metals is a growing problem with serious adverse health effects. Therefore, detection and remediation of heavy metals is a major task for analytical chemists and environmental engineers. We propose herein a biomimetic device for solving this problem. The device releases sensing or remediation chemicals only in the presence of target contaminants, while it can stably flow in water for a long time in a benign polymer capsule in the absence the target. Our approach will change the sampling-testing-remediation method to the new seeking-responding-remediation (SRR). To achieve this goal, we propose to use DNAzyme-gated polymersomes for searching contaminants and remediation. Compared to dumping chemicals into water for remediation, our approach is more targeted with a higher efficiency. This project will be performed with our collaborator in the University of Bordeaux in France through NSERC's international collaboration program. Two local Canadian companies will also be involved to guide the project to make practical impacts.
Programme
Strategic Projects - Group
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
507070-2017
Name nom
Liu, Juewen
Department département
Chemistry
Organization id
33
Institution établissement
University of Waterloo
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2017
Competition year année de concours
2017
Award amount
197675
Program id
STPGP
Program name en
Strategic Projects - Group
Program name fr
Projets stratégiques - De groupe
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1584
Committee name en
Strategic Projects - Environment and Agriculture
Committee name fr
Projets stratégiques - Environnement et agriculture
Area of application code
1002
Area of application group en
Northern development
Area of application group fr
Développement du nord
Area of application en
Environment
Area of application fr
Environnement
Research subject code
3504
Research subject group en
Analytical chemistry
Research subject group fr
Chimie analytique
Research subject en
Bioanalytical chemistry
Research subject fr
Chimie bioanalytique
Partie
1
Nb partie
3
Application title
DNA-gated stimuli-responsive nanostructures for metal sensing and smart remediation
Keyword
NSERC
Application summary
Around 40% of the rivers and lakes in America are polluted, and this problem is much more serious in developing countries. In particular, water contamination by heavy metals is a growing problem with serious adverse health effects. Therefore, detection and remediation of heavy metals is a major task for analytical chemists and environmental engineers. We propose herein a biomimetic device for solving this problem. The device releases sensing or remediation chemicals only in the presence of target contaminants, while it can stably flow in water for a long time in a benign polymer capsule in the absence the target. Our approach will change the sampling-testing-remediation method to the new seeking-responding-remediation (SRR). To achieve this goal, we propose to use DNAzyme-gated polymersomes for searching contaminants and remediation. Compared to dumping chemicals into water for remediation, our approach is more targeted with a higher efficiency. This project will be performed with our collaborator in the University of Bordeaux in France through NSERC's international collaboration program. Two local Canadian companies will also be involved to guide the project to make practical impacts.