Grant: Operating Grant
University of Alberta
$523,932.00
The Role of Aha1p in the Hsp90 Chaperone Cycle
EF 2008-09
Résumé
The heat shock protein 90 (Hsp90) is a molecular chaperone that plays a central role in the development and progression of cancer. Many of the regulatory changes that occur in cancer cells are mediated by Hsp90 and inhibition of Hsp90 by drugs has been demonstrated to halt the growth of cancer cells in a variety of systems. The development of Hsp90 as a target in the treatment of cancer is hampered by the lack of understanding of its mechanism of action. Hsp90 itself is regulated by a large number of proteins called co-chaperones but how these proteins influence Hsp90 activity is only beginning to be revealed. This proposal is aimed at understanding how Hsp90 works on the molecular level and how its action changes the growth properties of cells that ultimately give rise to cancer cells. This research will allow for the potential of Hsp90 as a target in the treatment of human disease to be realized.
Programme
Operating Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
179277
Name
LaPointe Paul G
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
The Role of Aha1p in the Hsp90 Chaperone Cycle
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$523,932
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Hsp90; Molecular Chaperones; Protein Folding
Abstract
The heat shock protein 90 (Hsp90) is a molecular chaperone that plays a central role in the development and progression of cancer. Many of the regulatory changes that occur in cancer cells are mediated by Hsp90 and inhibition of Hsp90 by drugs has been demonstrated to halt the growth of cancer cells in a variety of systems. The development of Hsp90 as a target in the treatment of cancer is hampered by the lack of understanding of its mechanism of action. Hsp90 itself is regulated by a large number of proteins called co-chaperones but how these proteins influence Hsp90 activity is only beginning to be revealed. This proposal is aimed at understanding how Hsp90 works on the molecular level and how its action changes the growth properties of cells that ultimately give rise to cancer cells. This research will allow for the potential of Hsp90 as a target in the treatment of human disease to be realized.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
LaPointe, Paul G
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $523,932~ $0~
