Grant: Project Grant
McMaster University
$994,500.00
Regulatory solutions to the antibiotic production challenge
EF 2023-24
Résumé
Antibiotic resistance is fast becoming a global health crisis: disease-causing bacteria are no longer killed by existing antibiotics, and we urgently need new drugs to help treat infectious disease. Most antibiotics are made by bacteria known as 'Streptomyces'. These organisms have the ability to make many more antibiotics than anyone has ever seen - but the problem is that most antibiotics are not made when Streptomyces are grown in the lab.
We have developed a technology that allows us to identify all the different elements that control antibiotic production. In this project, we will identify and define these different control elements, and will use this knowledge to turn on the production of new antibiotics in Streptomyces.
Our findings have the potential to help deal with the impending antibiotic resistance crisis, and will provide tools that will enable future drug discovery.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
500419
Name
Elliot Marie A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Microbiology & Infectious Diseases
Projecttitle
Regulatory solutions to the antibiotic production challenge
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$994,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antibiotics; Dna Binding; Gene Regulation; Genetic Engineering; Microbial Genetics; Natural Products; Neisseria Gonorrhoeae; Reporter Assays; Streptomyces; Transcription Factors
Abstract
Antibiotic resistance is fast becoming a global health crisis: disease-causing bacteria are no longer killed by existing antibiotics, and we urgently need new drugs to help treat infectious disease. Most antibiotics are made by bacteria known as 'Streptomyces'. These organisms have the ability to make many more antibiotics than anyone has ever seen - but the problem is that most antibiotics are not made when Streptomyces are grown in the lab.
We have developed a technology that allows us to identify all the different elements that control antibiotic production. In this project, we will identify and define these different control elements, and will use this knowledge to turn on the production of new antibiotics in Streptomyces.
Our findings have the potential to help deal with the impending antibiotic resistance crisis, and will provide tools that will enable future drug discovery.
Competitiondate
202403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Elliot, Marie A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $994,500~ $0~
