Grant: Travel Awards - Institute Community Support

Cardiovascular disease is a group of high mortality heart and major vessel pathological processes, more and more people recognized its hazard on human health. Based on our recent researches, heat shock protein 27 play an important role in the homeostasis of the vessel wall and impact on inflammatory processes in pathological conditions involved in the development of atherosclerosis. In this study, we are intent to investigate the effect of heat shock protein 27 on Adenosine Triphosphate synthesis and Apo lipoprotein A stabilize, and the effect of heat shock protein 27 on cell's cholesterol uptake and exocytosis, check the relationship between the Adenosine Triphosphate synthase afa subunit and heat shock protein 27, find out the contribution of heat shock protein 27 on Adenosine Triphosphate synthase afa subunit's function on Adenosine Triphosphate synthesis and lipid transportation. In brief, we try to explore the potential of heat shock protein 27 as a new early diagnosis target and endogenous therapeutic for vascular disease.