Grant: Project Grant

Infection by Respiratory Syncytial Virus (RSV) is the causative agent of substantial morbidity and mortality in children, elderly but also all-aged adults with a compromised immune system or cardiopulmonary diseases. Despite intensive research, the development of efficient vaccine or treatment failed. The search for novel RSV treatment remains a priority. Particularly, more information is needed to understand how RSV interacts with cellular mechanisms and how it helps its replication or help the host defense. Identification of these virus-host interactions is necessary to identify novel drug targets amongst cellular proteins. Much remains unknown about how RSV interacts with cellular processes. Our research will address knowledge gaps in the understanding of the host-virus interaction influencing RSV infection. Outputs from this research will lead to the identification of novel targets for the development of urgently needed RSV antiviral therapies.