Grant: Operating Grant
University of Ottawa
$608,103.00
Elucidating the role of lysine acetylation in stress granule dynamics
EF 2014-15
Résumé
In response to nutrient limitations cells must quickly counteract these threats in order to survive. One way cells fight nutrient limitations is through changing the activity of proteins by the addition and removal of various modifications on amino acids, the basic building blocks of proteins. My laboratory is interested in the acetylation of the amino acid lysine, a protein modification that has been implicated in turning on/off a wide variety of proteins. We will study how lysine acetylation "rewires" the cell during times when nutrients are deprived. Understanding how cells adapt to changes in nutrients could lead to improvement in a wide variety of disease states associated with metabolic changes including cancer, diabetes and neurodegenerative diseases.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
322337
Name
Baetz Kristin K
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Elucidating the role of lysine acetylation in stress granule dynamics
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$608,103
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Biochemistry; Cancer; Genetics; Kat5/Nua4; Kdac And Kats; Lysine Acetylation; Proteomics; Stress Granules; Stress Response; Yeast Genetics And Molecular Biology
Abstract
In response to nutrient limitations cells must quickly counteract these threats in order to survive. One way cells fight nutrient limitations is through changing the activity of proteins by the addition and removal of various modifications on amino acids, the basic building blocks of proteins. My laboratory is interested in the acetylation of the amino acid lysine, a protein modification that has been implicated in turning on/off a wide variety of proteins. We will study how lysine acetylation "rewires" the cell during times when nutrients are deprived. Understanding how cells adapt to changes in nutrients could lead to improvement in a wide variety of disease states associated with metabolic changes including cancer, diabetes and neurodegenerative diseases.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Baetz, Kristin K
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $608,103~ $0~
