Grant: CIHR New Investigator
Unity Health Toronto
$300,000.00
Identifying the role of silent information regulator (Sirt1) in ventricular remodeling using genetic ablation and pharmacological strategies.
EF 2013-14
Résumé
Heart failure causes the heart muscle to increase in size (hypertrophy). This process, early on, helps the heart to cope with the damage caused by a heart attack or high blood pressure. Eventually though, the hypertrophy places added strain upon the heart, and it starts to fail. For the heart to hypertrophy, genes must be turned "on" by a series of chemical switches. How these switches work is poorly understood. However, activating these chemical switches causes early ageing, hence trying to stop this is very important!
The objectives of this project are to understand why these switches are turned "on" and "off". The main goal of the study is to develop new drugs that will stop these switches from turning "on" and prevent cell hypertrophy (and hopefully stop early ageing). Ultimately, we aim to stop patients from dying of heart failure and improve their quality of life.
Programme
CIHR New Investigator
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Other
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
301836
Name
Connelly Kim A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Health Professional Awards - New Investigators
Projecttitle
Identifying the role of silent information regulator (Sirt1) in ventricular remodeling using genetic ablation and pharmacological strategies.
Programtype2
Salary Programs
Orgnameinp2
Unity Health Toronto
Cihramount2
$300,000
Cihrequipment2
$0
Programname2
CIHR New Investigator
Keyworddelim
Extracellular Matrix; Heart Failure; Knockout Animals; Pharmacologic Therapy; Smad; Ventricular Remodeling
Abstract
Heart failure causes the heart muscle to increase in size (hypertrophy). This process, early on, helps the heart to cope with the damage caused by a heart attack or high blood pressure. Eventually though, the hypertrophy places added strain upon the heart, and it starts to fail. For the heart to hypertrophy, genes must be turned "on" by a series of chemical switches. How these switches work is poorly understood. However, activating these chemical switches causes early ageing, hence trying to stop this is very important!
The objectives of this project are to understand why these switches are turned "on" and "off". The main goal of the study is to develop new drugs that will stop these switches from turning "on" and prevent cell hypertrophy (and hopefully stop early ageing). Ultimately, we aim to stop patients from dying of heart failure and improve their quality of life.
Competitiondate
201312
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Connelly, Kim A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $300,000~ $0~
