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Grant: DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Unity Health Toronto

$120,000.00

Photoacoustics and Ultrasound for Acute Lung Injury

EF 2025-26

Résumé
Much like the sensation of drowning, the lungs of ICU patients are often filled with fluid as a result of severe infections such as COVID-19. Clinicians currently face significant challenges in assessing the extent of this fluid buildup, as accurate quantification often requires prolonged exposure to harmful radiation. Moreover, treatment is complicated by the fact that lung injury is rarely uniform, some regions may be severely damaged while others remain functional, making it difficult to target therapies effectively. In this project, we propose to develop novel, radiation-free approaches for monitoring pulmonary fluid accumulation in a simple, bedside-compatible manner. Our solution integrates ultrasound (US) and photoacoustic (PA) imaging, two complementary techniques that use harmless light and sound to visualize lung injury. This approach offers enhanced regional specificity, enabling precise mapping of lung damage. By allowing real-time assessment of how the lungs respond to treatment, this technology could help physicians adjust therapies earlier, track recovery and prevent complications. I will validate this technology against established clinical standards, with the ultimate goal of providing physicians with an accessible tool to monitor disease progression and optimize treatment strategies for critically ill patients.
Programme
DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Other
Type
Grant
Source
CIHR Funding Decisions Database

Tel que publié

Id
559422
Name
Sauntharrajan Babishaa
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
DT1 (Biomedical and/or Clinical Research) CGRS Doctoral
Projecttitle
Photoacoustics and Ultrasound for Acute Lung Injury
Programtype2
Studentship Programs
Orgnameinp2
Unity Health Toronto
Cihramount2
$120,000
Cihrequipment2
$0
Programname2
DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
Keyworddelim
Acute Respiratory Distress Syndrome; Biomarker Validation; Computed Tomography; Functional And Strucutral; Lung Injuries; Non-Ionizing; Oxygenation; Perfusion; Photoacoustic Imaging; Ultrasound Imaging
Abstract
Much like the sensation of drowning, the lungs of ICU patients are often filled with fluid as a result of severe infections such as COVID-19. Clinicians currently face significant challenges in assessing the extent of this fluid buildup, as accurate quantification often requires prolonged exposure to harmful radiation. Moreover, treatment is complicated by the fact that lung injury is rarely uniform, some regions may be severely damaged while others remain functional, making it difficult to target therapies effectively. In this project, we propose to develop novel, radiation-free approaches for monitoring pulmonary fluid accumulation in a simple, bedside-compatible manner. Our solution integrates ultrasound (US) and photoacoustic (PA) imaging, two complementary techniques that use harmless light and sound to visualize lung injury. This approach offers enhanced regional specificity, enabling precise mapping of lung damage. By allowing real-time assessment of how the lungs respond to treatment, this technology could help physicians adjust therapies earlier, track recovery and prevent complications. I will validate this technology against established clinical standards, with the ultimate goal of providing physicians with an accessible tool to monitor disease progression and optimize treatment strategies for critically ill patients.
Competitiondate
202511
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Sauntharrajan, Babishaa
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $120,000~ $0~
Unity Health Toronto - $120,000 Grant (2025-26) | Canada Spends