Grant: Project Grant

The entire medical knowledge generation process is based on the belief that research outputs are rigorous and reproducible. However, initial investigations have determined that not all research is reproducible. If patients and healthcare providers are using clinical practice guidelines (CPGs) for shared decision making, it is essential that the foundational systematic reviews included are rigorous and reproducible. Working with Guidelines International Network, a global leader in CPGs, we will ask CPG experts whether the reproducibility of systematic reviews included in CPGs is important. We will also attempt to reproduce 101 systematic reviews included in CPGs. Finally, we will present our reproducibility results with the CPG experts and ask them whether the reproducibility results would change their recommendations about the CPGs.