Grant: Operating Grant
University of Alberta
$1,003,550.00
Lymphocyte Proteinases
EF 2013-14
Résumé
Cytotoxic T lymphocytes serve to protect us against viruses and cancers. When their activities are not properly regulated they lead to autoimmune diseases such as diabetes and multiple sclerosis. We believe that by understanding the molecular mechanisms employed by CTL to destroy pathogenic cells we will be able to develop novel immunotherapies. Increased activity will be useful in cancer, reduced effectiveness may lead to novel treatments for autoimmune diseases.
Programme
Operating Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
290723
Name
Bleackley Robert C
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Lymphocyte Proteinases
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$1,003,550
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Apoptosis; Autoimmunity; Caspases; Cytotoxic T Lymphocytes; Granzymes; Immunology
Abstract
Cytotoxic T lymphocytes serve to protect us against viruses and cancers. When their activities are not properly regulated they lead to autoimmune diseases such as diabetes and multiple sclerosis. We believe that by understanding the molecular mechanisms employed by CTL to destroy pathogenic cells we will be able to develop novel immunotherapies. Increased activity will be useful in cancer, reduced effectiveness may lead to novel treatments for autoimmune diseases.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Bleackley, Robert C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,003,550~ $0~
