Grant: CIHR-ICRH Travel Awards - General pool
McGill University
$1,500.00
Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
EF 2022-23
Résumé
Although there is a known mutually antagonistic nature of TH1 and TH2 immune responses, the role of the former in asthma pathogenesis is unclear. We adopted an ovalbumin (OVA)-induced Brown-Norway (BN) rat “asthma” model with the co-administration of polyinosinic:polycytidylic acid (PIC), which is a mimic of viral double-stranded RNA that initiates interferon responses. Hypothesis and aims: We hypothesized that the co-administration of PIC during intrapulmonary allergen challenges results in elevated TH1 immunopathology, which corresponds to a distinct disease phenotype. We aimed to investigate the effect of PIC co-administration on airway hyperresponsiveness (AHR), inflammation and remodelling, and to elucidate the impact of PIC-induced TH1 immunopathology on TH2 immunity and vice versa in the rat allergic asthma model.
Programme
CIHR-ICRH Travel Awards - General pool
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
480732
Name
Sun Rui
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Prcname2
Special Cases
Projecttitle
Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
Programtype2
Undefined
Orgnameinp2
McGill University
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - General pool
Keyworddelim
Airway Inflammation; Allergy; Asthma; Sensitized Rats; Synthetic Double-Stranded Rna
Abstract
Although there is a known mutually antagonistic nature of TH1 and TH2 immune responses, the role of the former in asthma pathogenesis is unclear. We adopted an ovalbumin (OVA)-induced Brown-Norway (BN) rat “asthma” model with the co-administration of polyinosinic:polycytidylic acid (PIC), which is a mimic of viral double-stranded RNA that initiates interferon responses. Hypothesis and aims: We hypothesized that the co-administration of PIC during intrapulmonary allergen challenges results in elevated TH1 immunopathology, which corresponds to a distinct disease phenotype. We aimed to investigate the effect of PIC co-administration on airway hyperresponsiveness (AHR), inflammation and remodelling, and to elucidate the impact of PIC-induced TH1 immunopathology on TH2 immunity and vice versa in the rat allergic asthma model.
Competitiondate
202301
Approvedterm2
1 yr 0 mth
Pinamesdelim
Sun, Rui
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,500~ $0~
