Grant: Project Grant
University of Toronto
$888,356.00
Mechanisms of mitochondrial DNA elimination in sperm
EF 2024-25
Résumé
In our cells, DNA is kept in two places, the nucleus and the mitochondrion. Nuclear DNA is inherited from both our parents, while mitochondrial DNA (mtDNA) is inherited only maternally. What ensures this maternal inheritance and why this unusual mode of inheritance exists has remained unclear. In this proposal we seek to answer these questions.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
524305
Name
Hurd Thomas R
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Cell Biology - Molecular/Fundamental
Projecttitle
Mechanisms of mitochondrial DNA elimination in sperm
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$888,356
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Drosophila; Mitochondria; Mitochondrial Dna; Nuclease; Spermatogenesis
Abstract
In our cells, DNA is kept in two places, the nucleus and the mitochondrion. Nuclear DNA is inherited from both our parents, while mitochondrial DNA (mtDNA) is inherited only maternally. What ensures this maternal inheritance and why this unusual mode of inheritance exists has remained unclear. In this proposal we seek to answer these questions.
Competitiondate
202503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hurd, Thomas R
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $888,356~ $0~
