Grant: CIHR-ICR / Cancer Research Society Partnership - Res. Grants-Survivorship

Perineural invasion (PNI) is the invasion of cancer cells into peripheral nerves. It is a risk factor for metastasis, recurrence, drug resistance, and neuropathic pain in cancers. We recently found that two proteins, CPLANE-1 and hemopexin, are overexpressed in PNI-competent breast cancer cells and patient tumors, suggesting their potential promoter roles in PNI. Therefore, this research will examine the roles of these proteins in the development of PNI and the survival of PNI cells. Given the connection of PNI to CPLANE-1, hemopexin and metastasis, we will also examine the direct roles of CPLANE-1 and hemopexin in metastasis. Overall, we expect this research to identify potential therapeutic targets to prevent and eliminate PNI, thereby improving the survival and quality of life of cancer patients in the future.