Grant: Project Grant
University of Alberta
$749,211.00
Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells
EF 2015-16
Résumé
It has recently been found that when our DNA is damaged by the formation of a DNA double-strand break, which happens about 10 times/cell/day in each of our cells, small RNAs are generated from the damaged site. We believe that these newly discovered RNAs play a critical role in the repair of this type of damage. Specifically, we believe that they are involved in shutting down nearby genes, to prevent the manufacture of potentially mutated proteins and that they help identify template DNA that matches the damaged DNA and can be used to faithfully repair the damage.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
345110
Name
Hendzel Michael J
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$749,211
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Argonaut Proteins; Chromatin; Dgcr8; Dna Damage Signaling; Dna Double-Strand Break; Drosha; Heterochromatin; Histone Methylation; Hp1; Rna Interference
Abstract
It has recently been found that when our DNA is damaged by the formation of a DNA double-strand break, which happens about 10 times/cell/day in each of our cells, small RNAs are generated from the damaged site. We believe that these newly discovered RNAs play a critical role in the repair of this type of damage. Specifically, we believe that they are involved in shutting down nearby genes, to prevent the manufacture of potentially mutated proteins and that they help identify template DNA that matches the damaged DNA and can be used to faithfully repair the damage.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hendzel, Michael J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $749,211~ $0~
