Grant: Catalyst Grant: Post Market Drug Safety and Effectiveness

Migraine is a common and often very debilitating condition for children and adolescents. When standard treatment strategies used at home fail, these young migraine sufferers may present to the Emergency Department (ED). However most medications used by physicians in the ED have not been studied in children. One of the common approaches in Canada is to combine two intravenous medications - metoclopramide and ketorolac. These two medications work very differently on different parts of the brain. While there are good scientific reasons to do this and it is a common practice among ED physicians working in Canada, the practice has never been formally studied. We propose a study to evaluate whether metoclopramide and ketorolac in combination is better than metoclopramide by itself in treating a migraine attack for paediatric patients in whom standard treatments have failed.