Grant: Project Grant
McGill University
$1,185,750.00
Cell biological role of the cancer-related gene SPOCD1 in the formation of mesenchymal-like cells in Glioblastoma
EF 2025-26
Résumé
Glioblastoma is a devastating and consistently fatal form of brain cancer. We have discovered a cell biological pathway that is involved in formation of this cancer. Disruption of the function of a gene controlling this pathway leads to enhanced growth and spread of glioblastoma tumors using a model in mice. When we analyze the tumors we found that one gene, called SPOCD1 was strongly upregulated. Glioblastoma tumors contain multiple types of cells and this diversity hampers the development of effective therapeutics. Mesenchymal-like cells are an aggressive cell state in glioblastoma. We believe that SPOCD1 plays a critical role in mesenchymal-like cell progression in glioblastoma and that by blocking SPOCD1 we can help slow the growth and spread of these devastating brain tumors.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
532294
Name
McPherson Peter S
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Cell Biology - Disease
Projecttitle
Cell biological role of the cancer-related gene SPOCD1 in the formation of mesenchymal-like cells in Glioblastoma
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$1,185,750
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Brain Tumors; Cell Biology; Dna Methylation; Glioblastoma; Protein Methylation; Spocd1
Abstract
Glioblastoma is a devastating and consistently fatal form of brain cancer. We have discovered a cell biological pathway that is involved in formation of this cancer. Disruption of the function of a gene controlling this pathway leads to enhanced growth and spread of glioblastoma tumors using a model in mice. When we analyze the tumors we found that one gene, called SPOCD1 was strongly upregulated. Glioblastoma tumors contain multiple types of cells and this diversity hampers the development of effective therapeutics. Mesenchymal-like cells are an aggressive cell state in glioblastoma. We believe that SPOCD1 plays a critical role in mesenchymal-like cell progression in glioblastoma and that by blocking SPOCD1 we can help slow the growth and spread of these devastating brain tumors.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McPherson, Peter S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,185,750~ $0~
