Grant: CIHR/Regional Partnership Program/Operating Grants
University of Saskatchewan
$107,022.00
A multifurcate quest for tumour-selective and immunosuppresant Mannich bases and related compounds
EF 2009-10
Résumé
The aims of the current proposal are to produce new drugs for two purposes. First, efforts will be made to develop new anticancer agents by examining a number of hypotheses which have been formulated with the aim of producing molecules which are much more toxic to cancers than normal cells. In addition, attempts will be made to produce new drugs which reverse multidrug resistance which then makes tumors more vulnerable to antineoplastic agents. An important feature of this investigation is to determine how these compounds behave in mammals, i.e., do they reach the cancer in the body or are there distribution problems? Second, new drugs will be sought which will enable organ transplantation to take place without the major side effects of currently available medications.
Programme
CIHR/Regional Partnership Program/Operating Grants
Bénéficiaire
Emplacement
Saskatchewan, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
202608
Name
Dimmock Jonathan R
Region
Saskatchewan
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Saskatchewan Health Research Foundation
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Pharmaceutical Sciences
Projecttitle
A multifurcate quest for tumour-selective and immunosuppresant Mannich bases and related compounds
Programtype2
Operating Grants
Orgnameinp2
University of Saskatchewan
Cihramount2
$107,022
Cihrequipment2
$0
Programname2
CIHR/Regional Partnership Program/Operating Grants
Keyworddelim
Anticancer Drugs; Cancer Research; Cytotoxicity; Immunosuppresant Agents; Mannich Bases; Unsaturated Ketones
Abstract
The aims of the current proposal are to produce new drugs for two purposes. First, efforts will be made to develop new anticancer agents by examining a number of hypotheses which have been formulated with the aim of producing molecules which are much more toxic to cancers than normal cells. In addition, attempts will be made to produce new drugs which reverse multidrug resistance which then makes tumors more vulnerable to antineoplastic agents. An important feature of this investigation is to determine how these compounds behave in mammals, i.e., do they reach the cancer in the body or are there distribution problems? Second, new drugs will be sought which will enable organ transplantation to take place without the major side effects of currently available medications.
Competitiondate
200909
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Dimmock, Jonathan R
Approvedterm
2 ans 0 mois
Cihrcontribution2
SPIR~ $107,022~ $0~
