Grant: Alliance Grants
University of Guelph
$180,036.00
The unexplored bioactivity of colostrum
EF 2024-25
Résumé
The Canadian dairy industry generates more than $6 billion in cash receipts, with sales increasing by 26% over the past decade. However, amongst all animals on farm dairy calves suffer from the highest rates of morbidity and mortality, with digestive disorders accounting for over half of illnesses and one-third of deaths during early life. Therefore, digestive disorders during early life represent a significant economic loss to dairy producers and pose a serious threat to animal health and welfare, and thus the profitability of the Canadian dairy industry. Colostrum, the first secretion produced after calving, contains a wide array of bioactive molecules that have an unrealized potential to promote optimal gut function and development in young calves and in-turn reduce the rates of digestive morbidity. The specific goal of this research project is to uncover the unexplored bioactivity of colostrum and to maximize strategic colostrum use to stimulate development and health in dairy calves during early life. The research objectives will focus on determining how prepartum cow factors influence the profile of colostrum bioactive compounds, how specific colostrum bioactive compounds impact calf development and metabolism, and strategies to optimize colostrum use after the first day of life to maximize long-term health and productivity. These objectives will result in maximizing the production value of dry cattle and colostrum, and will deliver knowledge to industry stakeholders that will improve calf health and development and reduce the current high rates of morbidity, mortality and antimicrobial use in production animals. As such, this project will increase both consumer trust in the Canadian dairy industry and economic efficiency of dairy farms, thereby ensuring the future sustainability and profitability of the Canadian dairy industry.
Programme
Alliance Grants
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
556284-2020
Name nom
Steele, Michael MA
Department département
Animal Biosciences
Organization id
24
Institution établissement
University of Guelph
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2020
Award amount
180036
Program id
ALLRP
Program name en
Alliance Grants
Program name fr
Subventions Alliance
Group en
RESEARCH PARTNERSHIPS
Group fr
PARTENARIATS DE RECHERCHE
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
102
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Animal management (animal diseases, breeding)
Area of application fr
Gestion des animaux (maladies animales, reproduction)
Research subject code
5511
Research subject group en
Animal biology
Research subject group fr
Biologie animale
Research subject en
Animal nutrition and husbandry
Research subject fr
Nutrition et élevage des animaux
Field of research list names en
Not available
Field of research list names fr
Non disponible
Socioeconomic objective list names en
Not available
Socioeconomic objective list names fr
Non disponible
Application title
The unexplored bioactivity of colostrum
Keywords
bioactive compounds; colostrum; dairy calf; gut development; gut health; immunoglobulin
Application summary
The Canadian dairy industry generates more than $6 billion in cash receipts, with sales increasing by 26% over the past decade. However, amongst all animals on farm dairy calves suffer from the highest rates of morbidity and mortality, with digestive disorders accounting for over half of illnesses and one-third of deaths during early life. Therefore, digestive disorders during early life represent a significant economic loss to dairy producers and pose a serious threat to animal health and welfare, and thus the profitability of the Canadian dairy industry. Colostrum, the first secretion produced after calving, contains a wide array of bioactive molecules that have an unrealized potential to promote optimal gut function and development in young calves and in-turn reduce the rates of digestive morbidity. The specific goal of this research project is to uncover the unexplored bioactivity of colostrum and to maximize strategic colostrum use to stimulate development and health in dairy calves during early life. The research objectives will focus on determining how prepartum cow factors influence the profile of colostrum bioactive compounds, how specific colostrum bioactive compounds impact calf development and metabolism, and strategies to optimize colostrum use after the first day of life to maximize long-term health and productivity. These objectives will result in maximizing the production value of dry cattle and colostrum, and will deliver knowledge to industry stakeholders that will improve calf health and development and reduce the current high rates of morbidity, mortality and antimicrobial use in production animals. As such, this project will increase both consumer trust in the Canadian dairy industry and economic efficiency of dairy farms, thereby ensuring the future sustainability and profitability of the Canadian dairy industry.