Grant: Planning and Dissemination Grant - Institute Community Support

This CIHR planning grant is focused on planning for the systematic evaluation of pharmacologic and valvular disease interventions impacting 750,000 Canadians living with cardiovascular disease. This work is urgently required as randomized controlled trials and clinical guidelines evaluating cardiovascular outcomes after pharmacological (e.g., guideline-directed medical therapies for heart failure and anti-platelet therapies for ischemic heart disease) and/or device (e.g., surgical or transcatheter aortic valve replacement for aortic valve disease) interventions have often failed to report on potential sex, race, and age-related differences. We will convene a multidisciplinary team to conduct an environmental scan and preliminary synthesis of relevant literature on sex, race, and age-related differences in cardiovascular outcomes in cardiovascular disease. Comprehensive search strategies will be produced to identify significant knowledge gaps and inform the prioritization of emerging systematic review topics for a larger CIHR project grant that is poised to transform clinical cardiovascular training and practice. This work will be performed collaboratively with patient partners, institutional library services, and the Canadian Cardiovascular Society.