Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$687,324.00
Reactive Oxygen Species, Bcl-2-Modifying Factor and Tubular Atrophy in Diabetic Kidneys
EF 2011-12
Résumé
Diabetic nephropathy (DN) is a major cause of morbidity and mortality in patients with diabetes. It is estimated that approximately 30-50% of the diabetic patients in Canada and in the USA will eventually develop DN leading to chronic renal failure (or end stage renal disease).
Kidney fibrosis and tubular atrophy are closely associated with progression of DN though underlying mechanisms remain incompletely understood. This proposal, which concerns the molecular mechanism(s) of high glucose, oxidative stress and Bcl-2-modifying factor (a cell death gene) action on the development of programmed cell death in diabetic kidneys, will increase our knowledge and understanding of their role(s) in the pathogenesis of DN, thereby contributing directly to improved clinical treatment.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
252494
Name
Chan John S
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Hematology, Digestive Disease & Kidney
Projecttitle
Reactive Oxygen Species, Bcl-2-Modifying Factor and Tubular Atrophy in Diabetic Kidneys
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$687,324
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bcl-2-Modifying Factor; Diabetic Nephropathy; Glucose Signaling; Insulin Signaling; Kidney; Molecular Biology; Oxidative Stress; Physiology; Renin-Angiotensin System; Transgenic And Knockout Mice
Abstract
Diabetic nephropathy (DN) is a major cause of morbidity and mortality in patients with diabetes. It is estimated that approximately 30-50% of the diabetic patients in Canada and in the USA will eventually develop DN leading to chronic renal failure (or end stage renal disease).
Kidney fibrosis and tubular atrophy are closely associated with progression of DN though underlying mechanisms remain incompletely understood. This proposal, which concerns the molecular mechanism(s) of high glucose, oxidative stress and Bcl-2-modifying factor (a cell death gene) action on the development of programmed cell death in diabetic kidneys, will increase our knowledge and understanding of their role(s) in the pathogenesis of DN, thereby contributing directly to improved clinical treatment.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Chan, John S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $687,324~ $0~
