Grant: Project Grant

More than 5 million individuals live with Alzheimer's dementia (AD) in North American and this number is projected to double every 20 years. Frontal lobes function is thought to help in delaying the progression towards AD from a state that precedes AD, called Mild Cognitive Impairment (MCI). Frontal lobes function depends on robust frontal lobes plasticity. We have data demonstrating that patients with AD are impaired on frontal lobes plasticity and that this impairment could be rectified using neurostimulation. In this study, we plan to assess frontal lobes plasticity and function in patients with MCI and then evaluate whether we can improve frontal lobes plasticity and function in this population using neurostimulation. If successful, this study will provide a major advancement in identifying a novel approach to enhance frontal function in patients with MCI and eventually prevent AD.