Grant: Operating Grant
Institut de recherches cliniques de Montréal
$720,054.00
The inflammasome and dysfunctional adipose tissue: why should apoB-lipoproteins be targeted in humans
EF 2011-12
Résumé
While obesity increases the risk for cardiometabolic diseases like cardiovascular disease and diabetes, not all obese are at equal risk for these diseases. Unravelling the mechanisms that predict and promote diabetes is vital to identify and treat the highest-risk obese subjects and prevent their progression into diabetes.
In this project we will investigate the role of the particles that carry cholesterol and fat in the blood in the activation of certain immune pathways in human fat tissue and how this may promote metabolic diseases. We will also investigate whether omega-3 fatty acids, which are the type of fat found in fish oils, can provide a natural way for the reduction of these risks in humans, irrespective of weight-loss in obese subjects. To do so, we will enroll about 80 overweight and obese subjects in a 16-weeks dietary intervention using omega-3 fatty acids supplementation and examine their cardiometabolic risks before and after the intervention in the whole body and specifically in fat tissue biopsies.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
253614
Name
Faraj May
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Nutrition, Food & Health
Projecttitle
The inflammasome and dysfunctional adipose tissue: why should apoB-lipoproteins be targeted in humans
Programtype2
Operating Grants
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$720,054
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
16 Wks Omega-3 Fatty Acids Supplementation; Clinical Study In Obese Subjects; In Vivo And And Ex Vivo Models; Innate Immunity And Nlrp3 Inflammasome; Insulin Sensitivity And Secretion; Lipoprotein Metabolism; Postprandial Dietary Fat Clearance; Stable And Radioactive Isotope Tracing; White Adipose Tissue Function
Abstract
While obesity increases the risk for cardiometabolic diseases like cardiovascular disease and diabetes, not all obese are at equal risk for these diseases. Unravelling the mechanisms that predict and promote diabetes is vital to identify and treat the highest-risk obese subjects and prevent their progression into diabetes.
In this project we will investigate the role of the particles that carry cholesterol and fat in the blood in the activation of certain immune pathways in human fat tissue and how this may promote metabolic diseases. We will also investigate whether omega-3 fatty acids, which are the type of fat found in fish oils, can provide a natural way for the reduction of these risks in humans, irrespective of weight-loss in obese subjects. To do so, we will enroll about 80 overweight and obese subjects in a 16-weeks dietary intervention using omega-3 fatty acids supplementation and examine their cardiometabolic risks before and after the intervention in the whole body and specifically in fat tissue biopsies.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Faraj, May
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $720,054~ $0~
