Grant: Master's Award: Canada Graduate Scholarships

Inflammation is the body natural defense system, helping protect against infections, injuries, and tissue damage. While this response is essential for healing, it must remain balanced. If inflammation becomes excessive or poorly regulated, it can damage organs and lead to chronic diseases such as heart disorders and autoimmune conditions. Understanding how the immune system controls inflammation is crucial for preventing these outcomes.In this study, we will focus on how specific proteins, referred to as regulators, control the inflammatory response. Using specific immune cell types called macrophages from both mice and humans, which play a key role in managing inflammation, we will trigger the inflammatory response with components of bacterial cell walls called LPS.By analyzing these proteins, we aim to uncover how they balance inflammation and prevent it from becoming harmful. Our methods will include advanced techniques such as flow cytometry, Western blotting, and real-time PCR to measure both anti-inflammatory and pro-inflammatory markers. This will help us understand how these regulators function and affect the production of various biological markers produced by the immune system.This research will provide new insights into controlling inflammation, offering potential strategies to maintain immune balance and protect tissues from damage. These findings could have significant implications for treating inflammation-related diseases and preserving overall health.