Grant: Operating Grant
Université Laval
$766,905.00
Metabolic functions of the PTPase SHP-1 in insulin target tissues
EF 2011-12
Résumé
We have recently shown that the protein tyrosine phosphatase SHP-1 is expressed in metabolic tissues and may be involved in the development of obesity-related complications such as type 2 diabetes and fatty liver disease. The main goal of this project is to clarify the mechanisms by which SHP-1 causes these metabolic complications which will help in the design of novel therapeutic strategies.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
239671
Name
Marette André
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Metabolic functions of the PTPase SHP-1 in insulin target tissues
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$766,905
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adipose Tissue; Glucose Metabolism; Insulin Resistance; Insulin Signaling; Lipid Metabolism; Liver; Obesity; Protein Tyrosine Phosphatase; Skeletal Muscle; Steatosis
Abstract
We have recently shown that the protein tyrosine phosphatase SHP-1 is expressed in metabolic tissues and may be involved in the development of obesity-related complications such as type 2 diabetes and fatty liver disease. The main goal of this project is to clarify the mechanisms by which SHP-1 causes these metabolic complications which will help in the design of novel therapeutic strategies.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Marette, André
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $766,905~ $0~
